MOTsC 10mg

With FREE BAC Water

COAs available upon request

MOTS-c Peptide

Overview

MOTS-c is a mitochondrial-derived peptide encoded by mitochondrial DNA, making it distinct from most peptides used in biomedical research. Since its discovery, it has become an important subject of preclinical investigation due to its potential involvement in regulating cellular metabolism, energy balance, and adaptive stress responses. Although MOTS-c is not approved for therapeutic use, it continues to attract significant interest in laboratory and academic research focused on metabolism, exercise physiology, and healthy aging.

Research Applications

Current scientific research has explored MOTS-c across several key areas of interest:

Metabolic Regulation
Experimental studies have investigated MOTS-c for its potential role in glucose utilisation, lipid metabolism, and the maintenance of metabolic homeostasis.

Exercise Physiology
Preclinical findings suggest that MOTS-c may influence biological pathways associated with exercise adaptation, making it an area of interest in studies of endurance, skeletal muscle function, and physical performance.

Healthy Aging Research
Researchers are examining the peptide's involvement in cellular resilience and molecular pathways linked to longevity and age-related metabolic health.

Cellular Stress Response
MOTS-c has also been evaluated for its potential role in helping cells respond to oxidative stress and metabolic challenges, with ongoing studies investigating its contribution to cellular protection mechanisms.

These areas of investigation have positioned MOTS-c as a promising research molecule within the field of mitochondrial biology, particularly in studies involving energy metabolism, cellular adaptation, and the biology of aging.

Technical Specifications

• Chemical Name: Mitochondrial-Derived Peptide MOTS-c
• Alternative Names: MOTSc; Mitochondrial Open Reading Frame of the 12S rRNA Type-c
• Molecular Formula: C₃₇₇H₆₄₀N₁₀₆O₁₂₆S
• Molecular Weight: Approximately 2171 g/mol
• Amino Acid Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu
• CAS Number: 1465911-04-7
• Peptide Classification: Mitochondrial-Derived Peptide (MDP)

Storage Recommendations

• Lyophilized MOTS-c is stable at room temperature for short-term handling.
• For long-term preservation, store at −20 °C or below.
• After reconstitution, refrigerate between 2 °C and 8 °C. Stability following reconstitution will depend on the solvent and storage conditions.

Solubility

MOTS-c is generally soluble in sterile water and compatible aqueous buffer solutions, with solubility varying according to formulation and purity.

References

Lee, C., Zeng, J., Drew, B. G., et al. (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism, 21(3), 443–454.

Lu, H., Tang, H., He, J., et al. (2019). MOTS-c peptide regulates adipose homeostasis to prevent metabolic dysfunction. Nature Communications, 10, 468.

Shen, W., & He, J. (2020). MOTS-c: A novel mitochondrial signaling peptide with implications for aging and metabolic regulation. Frontiers in Endocrinology, 11, 605.

Research compound only. Not for human consumption