GHK-CU

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MOTS-c Peptide

Overview

MOTS-c is a naturally occurring peptide encoded by mitochondrial DNA, distinguishing it from most peptides investigated in biomedical research. It has attracted considerable attention in preclinical studies because of its potential involvement in metabolic regulation, energy balance, and cellular adaptation to stress. Although it is not approved for clinical or therapeutic use, MOTS-c continues to be widely explored in laboratory and academic settings, particularly in research related to metabolism, aging, and physical performance.

Research Applications

Current preclinical research has identified several areas where MOTS-c may play an important role:

Metabolic Function
Experimental studies have examined MOTS-c for its potential influence on glucose utilization, lipid metabolism, and overall metabolic balance.

Exercise Science
Research suggests that MOTS-c may reproduce or enhance certain physiological adaptations associated with exercise, making it an area of interest for studies involving endurance, muscle function, and athletic performance.

Healthy Aging
Scientists are investigating the peptide's potential involvement in cellular maintenance mechanisms and biological pathways associated with longevity and age-related health.

Cellular Stress Adaptation
MOTS-c has also been studied for its possible ability to support cellular resilience by helping cells respond to oxidative stress and metabolic challenges.

Collectively, these findings position MOTS-c as a promising subject within mitochondrial peptide research, with particular relevance to metabolism, energy regulation, and the biology of aging. Further research is required to better understand its mechanisms and potential applications.

Technical Specifications

• Chemical Name: Mitochondrial-Derived Peptide MOTS-c
• Alternative Names: MOTSc; Mitochondrial Open Reading Frame of the 12S rRNA Type-c
• Molecular Formula: C₃₇₇H₆₄₀N₁₀₆O₁₂₆S
• Molecular Weight: Approximately 2171 g/mol
• Amino Acid Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu
• CAS Number: 1465911-04-7
• Peptide Class: Mitochondrial-Derived Peptide (MDP)

Storage Recommendations

• The lyophilized peptide remains stable at room temperature for short durations.
• For extended storage, maintain at temperatures of −20 °C or lower.
• After reconstitution, store refrigerated between 2 °C and 8 °C. Stability following reconstitution will depend on the solvent and storage conditions.

Solubility

Depending on its formulation and purity, MOTS-c can be dissolved in sterile water or appropriate aqueous buffer solutions.

References

Lee, C., Zeng, J., Drew, B. G., et al. (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism, 21(3), 443–454.

Lu, H., Tang, H., He, J., et al. (2019). MOTS-c peptide regulates adipose homeostasis to prevent metabolic dysfunction. Nature Communications, 10, 468.

Shen, W., & He, J. (2020). MOTS-c: A novel mitochondrial signaling peptide with implications for aging and metabolic regulation. Frontiers in Endocrinology, 11, 605.

Research compound only. Not for human consumption