CJC-1295 + DAC 5mg

With FREE BAC Water

COAs available upon request

CJC-1295 with DAC

Overview

CJC-1295 with DAC (Drug Affinity Complex) is a synthetic analogue of Growth Hormone-Releasing Hormone (GHRH) engineered to provide prolonged biological activity. The inclusion of the Drug Affinity Complex significantly extends the peptide's circulating half-life compared with the non-DAC variant, making it particularly valuable for laboratory studies investigating sustained GHRH receptor activation.

Although intended exclusively for research applications, CJC-1295 with DAC has become a widely studied peptide in experimental models involving growth hormone regulation, metabolic function, and tissue physiology.

Research Applications

Preclinical investigations have examined CJC-1295 with DAC across several areas of scientific interest:

Growth Hormone Regulation
Research has demonstrated that CJC-1295 with DAC can promote prolonged pulsatile release of growth hormone, allowing investigators to study the effects of extended GHRH receptor stimulation over time.

Metabolic Research
Experimental models have explored its potential influence on glucose metabolism, lipid utilisation, energy balance, and body composition, making it relevant to studies of metabolic regulation.

Protein Synthesis & Tissue Biology
Researchers continue to investigate the peptide's potential involvement in cellular recovery processes, protein synthesis, and pathways associated with tissue maintenance and regeneration.

Pharmacokinetic Comparison
The extended half-life provided by the Drug Affinity Complex allows direct comparison with CJC-1295 without DAC, enabling studies that evaluate how prolonged receptor activation influences physiological responses.

These characteristics have established CJC-1295 with DAC as an important research tool for laboratories investigating long-acting GHRH analogues and their effects on endocrine signalling and metabolic physiology.

Technical Specifications

• Chemical Name: CJC-1295 with Drug Affinity Complex (DAC)
• Alternative Names: DAC-GRF(1-29); Modified GRF(1-29) with DAC
• Molecular Formula: C₁₅₂H₂₅₂N₄₄O₄₂
• Molecular Weight: Approximately 3368 g/mol
• Amino Acid Sequence: Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu
• CAS Number: 863288-34-0
• Peptide Classification: Synthetic GHRH analogue with Drug Affinity Complex (DAC)

Storage Recommendations

• Lyophilized CJC-1295 with DAC remains stable at room temperature for short-term handling.
• For long-term storage, keep the peptide at −20 °C or below.
• Following reconstitution, refrigerate between 2 °C and 8 °C. Stability after reconstitution will depend on the solvent and storage conditions.

Solubility

CJC-1295 with DAC is generally soluble in sterile water, dilute acetic acid, and compatible aqueous buffer solutions, depending on formulation and purity.

References

Teichman, S. L., Neale, A., Lawrence, B., Gagnon, C., et al. (2006). Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. Journal of Clinical Endocrinology & Metabolism, 91(3), 799–805.

Teichman, S. L., et al. (2004). CJC-1295, a long-acting growth hormone–releasing hormone analog: results of a phase I study. Journal of Clinical Endocrinology & Metabolism, 89(11), 5286–5292.

Research compound only. Not for human consumption