Cargrilintide 5mg

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COAs available upon request

Cagrilintide

Overview

Cagrilintide is a long-acting synthetic analogue of amylin, a peptide hormone naturally co-secreted with insulin by pancreatic β-cells. Structural modifications have been incorporated to extend its biological activity, making it a valuable research compound for investigating appetite regulation, energy homeostasis, and metabolic signalling.

Developed to study the physiological effects of sustained amylin receptor activation, Cagrilintide has become an important peptide in laboratory research exploring nutrient intake, gastrointestinal physiology, and endocrine function. Supplied exclusively for research applications, it continues to be investigated in experimental models of metabolic regulation and energy balance.

Research Applications

Preclinical and experimental studies have investigated Cagrilintide across several areas of scientific interest:

Amylin Receptor Activation
Researchers study Cagrilintide for its ability to activate amylin receptors, providing a useful model for understanding the role of amylin signalling in appetite regulation and metabolic physiology.

Energy Homeostasis
Experimental models have explored the peptide's influence on food intake, satiety signalling, and overall energy balance, making it an important research tool in metabolic biology.

Gastrointestinal Physiology
Laboratory investigations continue to examine Cagrilintide's effects on gastric emptying and digestive hormone interactions, contributing to a greater understanding of gastrointestinal regulation.

Combination Incretin Research
Cagrilintide is frequently studied alongside GLP-1 receptor agonists to investigate potential interactions between amylin and incretin pathways, allowing researchers to examine complementary mechanisms involved in metabolic and endocrine signalling.

These characteristics have established Cagrilintide as a valuable research compound for laboratories investigating amylin biology, appetite regulation, endocrine physiology, and metabolic function.

Technical Specifications

• Chemical Name: Cagrilintide
• Alternative Names: AM833
• Molecular Formula: C₁₉₄H₃₁₂N₅₄O₅₉S₂
• Molecular Weight: Approximately 4,187 g/mol
• Peptide Structure: Long-acting synthetic amylin analogue with lipid modification for extended activity
• CAS Number: 1415456-99-3
• Peptide Classification: Synthetic amylin receptor agonist

Storage Recommendations

• Lyophilized Cagrilintide remains stable at room temperature during short-term handling.
• For long-term storage, keep the peptide at −20 °C or below.
• Following reconstitution, refrigerate between 2 °C and 8 °C. Stability after reconstitution will depend on the solvent used and storage conditions.

Solubility

Cagrilintide is generally soluble in sterile water, bacteriostatic water, and compatible aqueous buffer solutions, depending on formulation and purity.

References

Lau, J., Bloch, P., Schäffer, L., et al. (2015). Discovery of the once-weekly glucagon-like peptide-1 (GLP-1) analogue semaglutide and related long-acting peptide technologies. Journal of Medicinal Chemistry, 58(18), 7370–7380.

Frias, J. P., Bastyr, E. J., Vignati, L., et al. (2021). The efficacy and safety of the amylin analogue cagrilintide in people with overweight or obesity. The Lancet, 398(10317), 2160–2172.

Kapitza, C., Dahl, K., Jacobsen, J. B., et al. (2021). Effects of the long-acting amylin analogue cagrilintide on appetite regulation, gastric emptying, and energy intake in clinical research. Diabetes, Obesity and Metabolism.

Research compound only. Not for human consumption