PT-141

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PT-141 (Bremelanotide)

Overview

PT-141, also known as Bremelanotide, is a synthetic heptapeptide derived from the naturally occurring hormone Alpha-Melanocyte Stimulating Hormone (α-MSH). Unlike phosphodiesterase-5 (PDE5) inhibitors, which primarily influence blood flow, PT-141 has been investigated for its activity within the central nervous system. Preclinical studies indicate that it functions as a non-selective agonist of melanocortin receptors, with particular affinity for the MC3R and MC4R receptor subtypes located in the hypothalamus. These receptors are believed to play important roles in regulating neural pathways involved in sexual behaviour and arousal.

PT-141 is supplied as a lyophilized peptide exclusively for laboratory and scientific research.

Research Applications

Experimental studies have investigated PT-141 across several areas of neurobiological and receptor-based research:

Melanocortin Receptor Activity
Research has focused on PT-141's interaction with melanocortin receptors, particularly MC4R, to better understand how activation of these receptors influences central nervous system signalling associated with physiological arousal.

Models of Sexual Function
PT-141 has been widely evaluated in preclinical models of Hypoactive Sexual Desire Disorder (HSDD) and Erectile Dysfunction (ED). These investigations examine central neurological mechanisms in contrast to therapies that primarily target peripheral vascular function.

Circulatory Shock Research
Earlier laboratory studies explored the peptide's potential role in haemorrhagic shock models due to the involvement of melanocortin receptors in cardiovascular regulation and blood pressure control.

Inflammatory Pathways
As an analogue of α-MSH, PT-141 has also been investigated for its potential influence on inflammatory signalling through the melanocortin system.

These areas of research have established PT-141 as an important tool for studying receptor pharmacology, neurobiology, and central mechanisms involved in physiological arousal and related signalling pathways.

Technical Specifications

• Chemical Name: Bremelanotide (PT-141)
• Alternative Names: PT141; Cyclo-[Nle4, Asp5, D-Phe7, Lys10]-α-MSH
• Molecular Formula: C₅₀H₆₈N₁₄O₁₀
• Molecular Weight: 1025.2 g/mol
• Peptide Sequence: Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-OH (cyclic lactam bridge)
• CAS Number: 189691-06-3
• Peptide Classification: Synthetic melanocortin receptor agonist and α-MSH analogue

Storage Recommendations

• Lyophilized PT-141 remains stable at room temperature for short-term handling.
• For extended storage, keep frozen at −20 °C or below.
• Following reconstitution, store refrigerated between 2 °C and 8 °C. Stability after mixing will vary depending on the solvent and storage conditions.

Solubility

PT-141 readily dissolves in sterile water, normal saline, or bacteriostatic water and typically reconstitutes without the need for acidic buffering solutions.

References

Pfaus, J. G., et al. (2004). Selective facilitation of sexual solicitation in the female rat by a melanocortin receptor agonist. Proceedings of the National Academy of Sciences, 101(27), 10201–10204.

Molinoff, P. B., et al. (2003). PT-141: A melanocortin agonist for the treatment of sexual dysfunction. Annals of the New York Academy of Sciences, 994(1), 96–102.

Diamond, L. E., et al. (2004). Co-administration of low doses of intranasal PT-141, a melanocortin receptor agonist, and sildenafil causes synergistic facilitation of erectile response in rats. Urology, 65(4), 755–759.

Research compound only. Not for human consumption