{"product_id":"pt-141","title":"PT-141","description":"\u003ch3\u003eWith \u003cstrong\u003e\u003cem\u003eFREE\u003c\/em\u003e\u003c\/strong\u003e BAC Water\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eCOAs available upon request\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2\u003e\u003cspan\u003ePT-141 (Bremelanotide)\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch3\u003e\u003cspan\u003eOverview\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"isSelectedEnd\"\u003e\u003cspan\u003ePT-141, also known as Bremelanotide, is a synthetic heptapeptide derived from the naturally occurring hormone Alpha-Melanocyte Stimulating Hormone (α-MSH). Unlike phosphodiesterase-5 (PDE5) inhibitors, which primarily influence blood flow, PT-141 has been investigated for its activity within the central nervous system. Preclinical studies indicate that it functions as a non-selective agonist of melanocortin receptors, with particular affinity for the MC3R and MC4R receptor subtypes located in the hypothalamus. These receptors are believed to play important roles in regulating neural pathways involved in sexual behaviour and arousal.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"isSelectedEnd\"\u003e\u003cspan\u003ePT-141 is supplied as a lyophilized peptide exclusively for laboratory and scientific research.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cspan\u003eResearch Applications\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"isSelectedEnd\"\u003e\u003cspan\u003eExperimental studies have investigated PT-141 across several areas of neurobiological and receptor-based research:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"isSelectedEnd\"\u003e\u003cstrong\u003e\u003cspan\u003eMelanocortin Receptor Activity\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003eResearch has focused on PT-141's interaction with melanocortin receptors, particularly MC4R, to better understand how activation of these receptors influences central nervous system signalling associated with physiological arousal.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"isSelectedEnd\"\u003e\u003cstrong\u003e\u003cspan\u003eModels of Sexual Function\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003ePT-141 has been widely evaluated in preclinical models of Hypoactive Sexual Desire Disorder (HSDD) and Erectile Dysfunction (ED). These investigations examine central neurological mechanisms in contrast to therapies that primarily target peripheral vascular function.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"isSelectedEnd\"\u003e\u003cstrong\u003e\u003cspan\u003eCirculatory Shock Research\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003eEarlier laboratory studies explored the peptide's potential role in haemorrhagic shock models due to the involvement of melanocortin receptors in cardiovascular regulation and blood pressure control.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"isSelectedEnd\"\u003e\u003cstrong\u003e\u003cspan\u003eInflammatory Pathways\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003eAs an analogue of α-MSH, PT-141 has also been investigated for its potential influence on inflammatory signalling through the melanocortin system.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"isSelectedEnd\"\u003e\u003cspan\u003eThese areas of research have established PT-141 as an important tool for studying receptor pharmacology, neurobiology, and central mechanisms involved in physiological arousal and related signalling pathways.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cspan\u003eTechnical Specifications\u003c\/span\u003e\u003c\/h3\u003e\n\u003cul data-spread=\"false\"\u003e\n\u003cli\u003e\n\u003cstrong\u003e\u003cspan\u003eChemical Name:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e Bremelanotide (PT-141)\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e\u003cspan\u003eAlternative Names:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e PT141; Cyclo-\u003cspan data-placeholder-token=\"true\" class=\"text-token-text-primary cursor-text rounded-sm\"\u003e[Nle4, Asp5, D-Phe7, Lys10]\u003c\/span\u003e-α-MSH\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e\u003cspan\u003eMolecular Formula:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e C₅₀H₆₈N₁₄O₁₀\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e\u003cspan\u003eMolecular Weight:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e 1025.2 g\/mol\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e\u003cspan\u003ePeptide Sequence:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-OH (cyclic lactam bridge)\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e\u003cspan\u003eCAS Number:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e 189691-06-3\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e\u003cspan\u003ePeptide Classification:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e Synthetic melanocortin receptor agonist and α-MSH analogue\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cspan\u003eStorage Recommendations\u003c\/span\u003e\u003c\/h3\u003e\n\u003cul data-spread=\"false\"\u003e\n\u003cli\u003e\u003cspan\u003eLyophilized PT-141 remains stable at room temperature for short-term handling.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eFor extended storage, keep frozen at \u003c\/span\u003e\u003cstrong\u003e\u003cspan\u003e−20 °C or below\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e.\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eFollowing reconstitution, store refrigerated between \u003c\/span\u003e\u003cstrong\u003e\u003cspan\u003e2 °C and 8 °C\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e. Stability after mixing will vary depending on the solvent and storage conditions.\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cspan\u003eSolubility\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"isSelectedEnd\"\u003e\u003cspan\u003ePT-141 readily dissolves in sterile water, normal saline, or bacteriostatic water and typically reconstitutes without the need for acidic buffering solutions.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cspan\u003eReferences\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"isSelectedEnd\"\u003e\u003cspan\u003ePfaus, J. G., et al. (2004). \u003c\/span\u003e\u003cem\u003e\u003cspan\u003eSelective facilitation of sexual solicitation in the female rat by a melanocortin receptor agonist.\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e Proceedings of the National Academy of Sciences, 101(27), 10201–10204.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"isSelectedEnd\"\u003e\u003cspan\u003eMolinoff, P. B., et al. (2003). \u003c\/span\u003e\u003cem\u003e\u003cspan\u003ePT-141: A melanocortin agonist for the treatment of sexual dysfunction.\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e Annals of the New York Academy of Sciences, 994(1), 96–102.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eDiamond, L. E., et al. (2004). \u003c\/span\u003e\u003cem\u003e\u003cspan\u003eCo-administration of low doses of intranasal PT-141, a melanocortin receptor agonist, and sildenafil causes synergistic facilitation of erectile response in rats.\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e Urology, 65(4), 755–759.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cem\u003e\u003cstrong\u003eResearch compound only. Not for human consumption\u003c\/strong\u003e\u003c\/em\u003e\u003c\/span\u003e\u003c\/p\u003e","brand":"My Store","offers":[{"title":"Default Title","offer_id":54735581053257,"sku":null,"price":28.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1019\/7493\/3833\/files\/PT-14110mg.png?v=1782667678","url":"https:\/\/truformlabs.co.uk\/products\/pt-141","provider":"TruForm Labs","version":"1.0","type":"link"}